Central nervous system depressant activities of melatonin in rats and mice.
Indian J Exp Biol
;
1998 Mar; 36(3): 257-63
Article
in English
| IMSEAR
| ID: sea-56870
ABSTRACT
Melatonin (10 and 20 mg/kg) potentiated pentobarbitone (45 mg/kg) induced hypnosis; it (50 and 100 mg/kg) decreased both total and ambulatory activity; produced (10, 25 and 50 mg/kg) hypothermia and possessed (10-400 mg/kg) significant analgesic property both in tail-flick and acetic acid-induced writhing tests. Melatonin in low dose (10 mg/kg) significantly reduced the forced-swimming induced immobility period per se and also reserpine induced immobility. While the antinociceptive effect of melatonin was sensitive to reversal by naloxone (2 mg/kg), other CNS depressant profile resembled the effects of benzodiazepines.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Female
/
Male
/
Central Nervous System Depressants
/
Animals
/
Melatonin
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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