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Inhibition of skin tumors in DMBA-induced complete carcinogenesis system in mice by garlic (Allium sativum).
Indian J Exp Biol ; 1990 May; 28(5): 405-8
Article in English | IMSEAR | ID: sea-56953
ABSTRACT
The chemopreventive action of garlic extract on DMBA-induced complete skin carcinogenesis system was studied in random bred, 6-7 weeks old, male Swiss albino mice. Topical weekly application of DMBA for 25 weeks at two dose levels, i.e. 200 nmol during the first week followed by 100 nmol during subsequent weeks, or 400 nmol during the first week followed by 200 nmol during subsequent weeks, resulted in 73.9% and 100% tumor incidences respectively. When garlic extract was topically applied twice daily for 3 days every week prior to above-stated dose schedules of DMBA, the incidences of tumors were reduced to 31.8% (P less than 0.01) and 43.4% (P less than 0.01) respectively.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plants, Medicinal / Skin Neoplasms / Male / Plant Extracts / 9,10-Dimethyl-1,2-benzanthracene / Garlic / Animals / Mice Language: English Journal: Indian J Exp Biol Year: 1990 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plants, Medicinal / Skin Neoplasms / Male / Plant Extracts / 9,10-Dimethyl-1,2-benzanthracene / Garlic / Animals / Mice Language: English Journal: Indian J Exp Biol Year: 1990 Type: Article