Ethanolic Zingiber officinale R. extract pretreatment alleviates isoproterenol-induced oxidative myocardial necrosis in rats.
Indian J Exp Biol
;
2006 Nov; 44(11): 892-7
Article
in English
| IMSEAR
| ID: sea-56955
ABSTRACT
Ethanolic Z. officinale (ZO) extract (200 mg/kg) pretreatment for 20 days in isoproterenol (ISO)-treated rats significantly increased the levels of endogenous myocardial antioxidants (catalase, superoxide dismutase and tissue glutathione), decreased the levels of serum marker enzymes (lactate dehydrogenase, creatine kinase, aspartate transaminase and alanine transaminase) and increased myocardial lipid peroxides. Histological examination of rat's heart section confirmed myocardial injury with ISO administration and near normal pattern with ethanolic ZO extract pretreatment. The results of the present study, for the first time, provide clear evidence that the ethanolic ZO extract pretreatment enhances the antioxidant defense against ISO-induced oxidative myocardial injury in rats and exhibit cardioprotective property.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Rats
/
Solvents
/
Female
/
Male
/
Plant Extracts
/
Biomarkers
/
Lipid Peroxidation
/
Rats, Wistar
/
Zingiber officinale
Type of study:
Evaluation studies
Language:
English
Journal:
Indian J Exp Biol
Year:
2006
Type:
Article
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