Effect of selective monoamine oxidase A and B inhibitors on footshock induced aggression in paired rats.
Indian J Exp Biol
;
1990 Aug; 28(8): 742-5
Article
in English
| IMSEAR
| ID: sea-56965
ABSTRACT
Effects of a selective monoamine oxidase (MAO)--A inhibitor, clorgyline, a selective MAO-B inhibitor, deprenyl, and a non-selective MAO inhibitor, nialamide, were investigated on footshock-induced aggression (FIA) in paired rats. The doses and pretreatment times of the inhibitors used were based on an earlier reported in vivo dose-response and time-course study. In addition, apomorphine, a dopaminergic receptor agonist, and beta-phenylethylamine, a preferred substrate for MAO-B, were also used to garner corroborative evidence. The results of the study indicate that selective MAO-A inhibitors are likely to attenuate FIA by augmenting central serotonergic activity, while selective MAO-B inhibitors accentuate the behaviour by facilitating dopaminergic activity. A permissive role for noradrenaline could not be delineated by the available data.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pain
/
Rats
/
Rats, Inbred Strains
/
Female
/
Male
/
Selegiline
/
Apomorphine
/
Clorgyline
/
Aggression
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
Similar
MEDLINE
...
LILACS
LIS