Reversal of changes of lipid peroxide, xanthine oxidase and superoxide dismutase by cardio-protective drugs in isoproterenol induced myocardial necrosis in rats.
Indian J Exp Biol
;
1989 Jul; 27(7): 625-7
Article
in English
| IMSEAR
| ID: sea-57048
ABSTRACT
In myocardial necrosis produced by isoproterenol (beta-adrenergic agonist) marked increase in creatine phosphokinase, phospholipase and significant decrease in cardiac glycogen and phospholipid levels were observed. The enhanced levels of lipid peroxides, xanthine oxidase activity and lowering of superoxide dismutase may lead to excessive formation of free radicals resulting in cardiac cell damage. Nifedipine--a calcium antagonist, Propranolol--a beta-blocker and guggulsterone a lipid lowering agent showed marked reversal of these metabolic changes related to ischemia induced by isoproterenol.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Oxidoreductases
/
Pregnenediones
/
Rats
/
Superoxide Dismutase
/
Xanthine Oxidase
/
Male
/
Cardiovascular Agents
/
Isoproterenol
/
Lipid Peroxides
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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