Ascorbic acid delays the development of tolerance to amphetamine induced anorexia but does not affect the reverse tolerance which develops to the locomotor activity.
Indian J Exp Biol
;
1994 Aug; 32(8): 540-3
Article
in English
| IMSEAR
| ID: sea-57050
ABSTRACT
Ascorbic acid (1 g/kg) accentuated anorectic and locomotor effects of amphetamine (5 mg/kg) and delayed development of tolerance to anorectic effect. On the contrary, it did not alter the pattern of reverse tolerance to increased locomotor activity. The results suggest that modulation of dopamine receptor sensitivity by ascorbic acid may be the reason for the delay in development of tolerance to amphetamine induced anorexia.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ascorbic Acid
/
Rats
/
Male
/
Anorexia
/
Rats, Wistar
/
Drug Tolerance
/
Amphetamine
/
Animals
/
Motor Activity
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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