GABA/BZ-and NMDA-receptor interaction in digoxin-induced convulsions in rats.
Indian J Exp Biol
;
1991 Jul; 29(7): 636-40
Article
in English
| IMSEAR
| ID: sea-57121
ABSTRACT
Digoxin (7.5 micrograms icv) induced 'pop-corn' type of convulsions and 100% mortality. The GABA-ergic agents produced varying degree of protection against digoxin-induced neurotoxicity. Diazepam (4 mg/kg) offered significant protection whereas pentobarbital (5 mg/kg) and baclofen (5 mg/kg) markedly reduced per cent mortality, but ethanol (2 g/kg), progabide (50 mg/kg) and muscimol (0.5 mg/kg) as well as GABA (50 mg/kg) could not offer significant protection in doses used. GABA-ergic agonists; GABA, baclofen, diazepam and pentobarbital when administered along with MK-801 (0.5 mg/kg) a non-competitive NMDA antagonist, a potentiation of anticonvulsant action of MK-801 was observed. MK-801 showed potent anticonvulsant profile in dose range (0.25-1 mg/kg) studied. A synergistic influence of Mg2+ and K+ ions on NMDA receptor antagonism was also observed. A role of GABA-ergic facilitation and NMDA antagonism as a potential anticonvulsant approach in digoxin-induced convulsions in rats has been suggested.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pentobarbital
/
Rats
/
Rats, Inbred Strains
/
Salts
/
Seizures
/
Baclofen
/
Female
/
Male
/
Dizocilpine Maleate
/
Receptors, N-Methyl-D-Aspartate
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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