Expression and functional activity of receptor-Ck in mononuclear cells of a homozygous hypercholesterolemic family.
Indian Heart J
;
2002 Jan-Feb; 54(1): 88-90
Article
in English
| IMSEAR
| ID: sea-5714
ABSTRACT
The study was addressed to explore the expression and functional activity of a novel cholesterol-specific cell surface receptor-Ck in a typical homozygous familial hypercholesterolemic family. Functional activity of receptor-Ck was characterized by its ability to downregulate Bcl-2 gene expression through a 47 kDa factor having an affinity for the sterol-regulatory element in the promoter region of this gene. The result of such a study revealed normal expression and functional activity of receptor-Ck accompanied by a lack of Apolipoprotein B-specific low-density lipoprotein receptor gene expression in the mononuclear cells derived from these patients. On the basis of these results, it is tempting to speculate that receptor-Ck may be involved in the maintenance of cellular cholesterol homeostasis observed in homozygous familial hypercholesterolemic patients.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Apolipoproteins B
/
Transcription Factors
/
Humans
/
Male
/
Receptors, LDL
/
Down-Regulation
/
Gene Expression Regulation
/
Family Health
/
Adolescent
/
Receptors, Lipoprotein
Language:
English
Journal:
Indian heart j
Year:
2002
Type:
Article
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