Short-term effects of thyroid hormones on lipogenic enzymes and 14C-acetate incorporation into various lipid classes: in vivo and in vitro studies.
Indian J Exp Biol
;
2001 May; 39(5): 431-5
Article
in English
| IMSEAR
| ID: sea-57310
ABSTRACT
Short-term effect of 3,5,3'-triiodothyronine (T3) and 3,5-diiodothyronine (T2) on lipid metabolism in the liver of Anabas testudineus was examined. In vivo injections of both T3 and T2 at a concentration of 10 ng/g body weight increased malic enzyme (ME), glucose-6-phosphate dehydrogenase (G6PDH) and 6-phosphogluconate dehydrogenase (6PGDH) activity compared to 6-propylthiouracil (6-PTU) treated group. Treatment of 6-PTU results in the accumulation 14C-acetate into fat and thyroid hormones' treatment reduce it. In vitro experiments show that malic enzyme activity is augmented only by high concentration of T3 (10(-7) M) where as all concentrations of T2 increase its activity. In vitro studies with T3 showed a biphasic effect on cholesterol content. Conversely T2 in vitro, reduced cholesterol content with all concentrations. From these results it can be concluded that both T3 and T2 have short-term effect on lipid metabolism in Anabas.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phosphogluconate Dehydrogenase
/
Thyroid Hormones
/
Triiodothyronine
/
Perciformes
/
Female
/
Cholesterol
/
Acetic Acid
/
Diiodothyronines
/
Malate Dehydrogenase (NADP/)
/
Lipid Metabolism
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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