Suppression of Con A induced lymphocyte transformation by sera from filarial patients with clinical manifestations.
Indian J Exp Biol
;
1991 Apr; 29(4): 352-4
Article
in English
| IMSEAR
| ID: sea-57390
ABSTRACT
Reduced lymphocyte transformation to Wuchereria bancrofti microfilariae excretory-secretory antigen and Con A were observed in clinical filarial patients. Pre-incubation of normal human peripheral blood mononuclear cells with sera from filarial patients with clinical manifestations such as hydrocele and elephantiasis suppressed Con A induced responses. Effect of fractionated clinical filarial serum on Con A induced lymphocyte transformation showed that the inhibitory activity was associated with high molecular weight serum fraction.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Wuchereria bancrofti
/
Elephantiasis, Filarial
/
Humans
/
Lymphocyte Activation
/
Cells, Cultured
/
Concanavalin A
/
Immune Tolerance
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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