Effect of gold on stimulation of reproductive function in immature female albino rats.
Indian J Exp Biol
;
2006 Dec; 44(12): 971-5
Article
in English
| IMSEAR
| ID: sea-57431
ABSTRACT
Significant increase in ovarian and uterine weight and stimulation of ovarian delta5-3beta-hydroxysteroid dehydrogenase (delta5-3beta-HSD) activity and elevation of serum estradiol level were observed following gold chloride (0.2 mg/kg body weight/day), s.c. administration in immature female albino rats. Moreover, normal cyclic changes of estrus were found in vaginal smears of these rats whereas the rats of other groups showed diestrus phase throughout the period of experiment. Histological study of ovary also showed Graafian follicle with ovum in rats treated with 0.2 mg/kg/day of gold proving stimulation of reproductive function, which was not found in the ovarian histological study of other groups including controls. Thus, the results suggest a significant stimulatory effect of gold chloride on female reproductive activity in immature rats. Further, since the above-mentioned changes were evident at a specific dose of gold chloride, the data may have some clinical implications on stimulation and enhancement of fertility in immature female rats.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Ovary
/
Rats
/
Reproduction
/
Uterus
/
Body Weight
/
Female
/
Rats, Wistar
/
Gold
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2006
Type:
Article
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