N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats.
Indian J Exp Biol
;
2001 Apr; 39(4): 360-4
Article
in English
| IMSEAR
| ID: sea-57480
ABSTRACT
N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, cholesterol and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explained by slightly less than 1 hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Blood Glucose
/
Male
/
Blood Proteins
/
Cholesterol
/
Circadian Rhythm
/
Rats, Wistar
/
Photoperiod
/
GABA Agonists
/
Lactic Acid
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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