Effect of antiulcerogenic drug, ranitidine, on intestinal absorption and digestive functions in mice.
Indian J Exp Biol
;
1989 Aug; 27(8): 721-4
Article
in English
| IMSEAR
| ID: sea-57503
ABSTRACT
Oral administration of antiulcerogenic drug ranitidine significantly inhibits glucose and amino acid uptake in small intestinal segments. It also inhibits activities of brush border membrane disaccharidases and alkaline phosphatase but increases the activity of leucine aminopeptidase. Kinetic analysis reveals noncompetitive and mixed type of inhibition for disaccharidases and alkaline phosphatase, respectively. In vitro addition of the drug to membrane preparation shows similar type of results as seen in vivo with the inhibition constant (ki) for sucrase, lactase, maltase and alkaline phosphatase as 12.5, 5, 11.5 and 19.5 mM, respectively.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ranitidine
/
Male
/
Digestion
/
Intestinal Absorption
/
Animals
/
Mice
/
Anti-Ulcer Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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