Subchronic oral hepatotoxicity of turmeric in mice--histopathological and ultrastructural studies.
Indian J Exp Biol
;
1998 Jul; 36(7): 675-9
Article
in English
| IMSEAR
| ID: sea-57506
ABSTRACT
Dietary administration of the whole spice turmeric (0.2%, 1.0%, 5.0%) or ethanolic turmeric extract (ETE, 0.05%, 0.25%) for 14 days, at doses reported to be cancer preventive in model systems, were found to be hepatotoxic in mice. Histopathological evaluation showed coagulative necrosis accompanied by a zone of regenerating parenchymal cells of liver. The ultrastructural changes in liver parenchymal cells were non-specific reaction to injury. Results suggest mouse to be a susceptible species for turmeric induced toxicity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Female
/
Plant Extracts
/
Microscopy, Electron
/
Administration, Oral
/
Condiments
/
Curcuma
/
Chemical and Drug Induced Liver Injury
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
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