Cardioprotective effect of cromakalim (potassium channel opener) in isoproterenol induced myocardial infarction in rats.
Indian J Exp Biol
;
1992 Jul; 30(7): 611-4
Article
in English
| IMSEAR
| ID: sea-57508
ABSTRACT
Animals pretreated with cromakalim (1 mg/kg,po) along with isoproterenol (85 mg/kg,sc) showed less myocardial degenerative changes on histopathological examinations when compared with those treated with isoproterenol alone. Cromakalim's beneficial effects on myocardium were in dose-dependent manner. Administration of cromakalim (po) lowered significantly the serum LDH and SGOT and depleted intracytoplasmic glycogen as demonstrated by periodic schiff staining procedure. Increase in blood clotting time was highly significant (P less than 0.001). The results suggest cardioprotective effect of cromakalim in isoproterenol induced myocardial infarction.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrroles
/
Aspartate Aminotransferases
/
Rats
/
Vasodilator Agents
/
Benzopyrans
/
Blood Coagulation
/
Female
/
Male
/
Verapamil
/
Cromakalim
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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