Age related toxic effects of endosulfan on certain enzymes of rat erythrocytes.
Indian J Exp Biol
;
1990 Jul; 28(7): 694-6
Article
in English
| IMSEAR
| ID: sea-57591
ABSTRACT
The effect of oral administration of endosulfan (12.5 mg/kg body weight), daily for 4 days was investigated on erythrocytes of female rats of 4 different age groups i.e. 15, 30, 70 and 365 days old. Erythrocyte membrane Na+, K(+)-ATPase and Mg2(+)-ATPase activities were significantly inhibited in all the age groups of rats. However, percent inhibition was maximum in the youngest animals. A significant decrease in the activity of erythrocyte glutathione reductase was observed in 30 and 70 days old rats whereas a significant increase in the activity of glucose-6-phosphate dehydrogenase (G-6-PD) was observed in these groups. The increase in G-6-PD activity may be a physiological response to compensate for decrease in the reduced glutathione level which results from decrease in the activity of glutathione reductase.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Aging
/
Drug Resistance
/
Cell Membrane Permeability
/
Age Factors
/
Endosulfan
/
Erythrocytes
/
Glutathione
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1990
Type:
Article
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