Sex differences in oxidative stress induced by benzene in rats.

Verma, Yeshvandra; Rana, S V S

Verma, Yeshvandra; Rana, S V S.

Indian J Exp Biol ; 2004 Jan; 42(1): 117-20

Article in English | IMSEAR | ID: sea-57658

ABSTRACT

ABSTRACT

Role of sex differences on oxidative stress induced by benzene has been studied in liver, kidney and lungs of rat. It was observed that benzene administration enhanced lipid peroxidation in liver, kidney and lungs of rat, nevertheless, significant variations were recorded in male and female rats. Decrease of GSH and CYTP(450)2E1 was higher in female rats than male rats except lungs. The results suggest that oxidative stress induced by benzene is higher in female rats.

Subject(s)

Animals; Benzene/pharmacology; Cytochrome P-450 CYP2E1/metabolism; Female; Glutathione/metabolism; Kidney/metabolism; Lipid Peroxidation; Liver/metabolism; Lung/metabolism; Male; Oxidation-Reduction; Oxidative Stress; Rats; Sex Factors

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Oxidation-Reduction / Rats / Benzene / Female / Male / Lipid Peroxidation / Sex Factors / Oxidative Stress / Cytochrome P-450 CYP2E1 / Glutathione Language: English Journal: Indian J Exp Biol Year: 2004 Type: Article

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