Molecular mechanics aided design of antineoplastic agents from ruthenium coordinate complexes.
Indian J Exp Biol
;
1999 Jul; 37(7): 667-70
Article
in English
| IMSEAR
| ID: sea-57666
ABSTRACT
Through energy minimization using molecular mechanics force field four ruthenium cordinate complexes have been synthesized. Compound I to IV showed antineoplastic activity with varying degree on EAC bearing mice. Mode of action may be through inhibition of antioxidant property of tumor cell as evident from lipid peroxidase activity. Among the complexes Bis pyridine tetrachloro ruthenium exhibits highest order of activity with respect to increase mean survival time, inhibition of tumour volume, total blood count, hemoglobin and lipid peroxidase activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Drug Design
/
Ruthenium Compounds
/
Animals
/
Mice
/
Neoplasms, Experimental
/
Antineoplastic Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
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