Effect of alpha-tocopherol on doxorubicin-induced changes in rat liver and heart microsomes.
Indian J Exp Biol
;
1991 Aug; 29(8): 782-5
Article
in English
| IMSEAR
| ID: sea-57720
ABSTRACT
Rats were treated with doxorubicin (2.5 mg/kg body wt, iv) once a week for 8 weeks. Alpha-Tocopherol (400 mg/kg body wt/day) was co-administered orally for 2 months. Cytochrome-P450 (Cyt-P450) and Cytochrome-b5 (Cyt-b5) levels decreased significantly in doxorubicin treated rats. Significant decreases were observed in glucose-6-phosphatase, Cyt-P450 and Cyt-b5 reductase activities. In vitro lipid peroxidation study showed that alpha-tocopherol significantly minimises the lipid peroxide formation by doxorubicin. There was a significant change in microsomal cholesterol and phospholipid levels. Alpha-Tocopherol co-administration reduced the alterations in xenobiotic metabolising system and microsomal lipid levels. The results were discussed with reference to drug metabolising enzymes, lipid peroxidation and antioxidant nature of alpha-tocopherol.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Vitamin E
/
Male
/
Microsomes, Liver
/
Doxorubicin
/
Heart
/
Animals
/
Microsomes
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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