Role of Moringa oleifera on enterochromaffin cell count and serotonin content of experimental ulcer model.
Indian J Exp Biol
;
2007 Aug; 45(8): 726-31
Article
in English
| IMSEAR
| ID: sea-57732
ABSTRACT
The present study has been undertaken to observe the effect of aqueous extract of M. oleifera (MO) leaf (300mg/kg body weight) on mean ulcer index, enterochromaffin (EC) cells and serotonin (5-hydroxytryptamine; 5-HT) content of ulcerated gastric tissue. Ulceration was induced by using aspirin (500 mg/kg, po), cerebellar nodular lesion and applying cold stress. In all cases increased mean ulcer index in gastric tissue along with decreased EC cell count was observed with concomitant decrease of 5-HT content. Pretreatment with MO for 14 days decreased mean ulcer index, increased both EC cell count and 5-HT content in all ulcerated group, but treatment with ondansetron, a 5-HT3 receptor antagonist, along with MO pretreatment increased mean ulcer index, decreased 5-HT content without any alteration in EC cell count. The results suggest that the protective effect of MO on ulceration is mediated by increased EC cell count and 5-HT levels which may act via 5-HT3 receptors on gastric tissue.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Rats, Inbred Strains
/
Stomach Ulcer
/
Water
/
Plant Extracts
/
Serotonin
/
Cell Count
/
Moringa oleifera
/
Disease Models, Animal
/
Enterochromaffin Cells
Language:
English
Journal:
Indian J Exp Biol
Year:
2007
Type:
Article
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