Radiosensitizing effect of plumbagin on mouse melanoma cells grown in vitro.
Indian J Exp Biol
;
1996 Sep; 34(9): 857-8
Article
in English
| IMSEAR
| ID: sea-57800
ABSTRACT
Mouse melanoma cells were treated with plumbagin, a naphthoquinone, from the plant Plumbago rosea at 0.5 microgram/ml (PI) for 60 min either alone or followed by 2 Gy gamma radiation (RT). Response to the different treatments was assessed by following the cell growth up to 5 days post treatment. PI alone produced a significant decrease in the cell count on days 3 and 4, whereas RT treatment significantly enhanced the growth inhibitory effect when compared to RT or PI alone. These findings suggests the radiosensitizing effect of PI on mouse melanoma cells in vitro, supporting the earlier in vivo findings.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Radiation-Sensitizing Agents
/
Melanoma, Experimental
/
Tumor Cells, Cultured
/
Cell Division
/
Naphthoquinones
/
Animals
/
Mice
/
Mice, Inbred C57BL
Language:
English
Journal:
Indian J Exp Biol
Year:
1996
Type:
Article
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