Detection of rabies virus in different tissues of experimentally infected mice at preclinical and postclinical stages of the disease.
Indian J Exp Biol
;
1992 Oct; 30(10): 877-80
Article
in English
| IMSEAR
| ID: sea-57892
ABSTRACT
Rabies fixed virus (CVS) was passaged 10 times in mice by intramuscular (im) route followed by experimental inoculation of the titrated virus in 4 groups of mice with the dose of 0.1 ml of 1000 mouse (LD50 0.03 ml) using intracerebral (ic), intravenous (iv), intramuscular (im), intraocular (io), and intranasal (in) routes respectively. No marked variation in clinical signs due to variation of routes could be detected. Involvement of brain with io route could be detected even in preclinical stage. Although the virus could be detected in the postclinical stage in all the tissues under study (brain, skin, salivary gland and corneal impression), with io and ic routes spread of the virus was observed in comparatively higher concentrations.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabies
/
Rabies virus
/
Salivary Glands
/
Skin
/
Brain
/
Cornea
/
Animals
/
Mice
/
Antigens, Viral
Type of study:
Diagnostic study
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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