Tissue changes induced by enterotoxic preparations of Salmonella weltevreden in ligated rabbit gut segments.

ABSTRACT

Culture filtrates and cell lysates of two strains of S. weltevreden which caused dilation of ligated rabbit gut segments (characteristic associated with the enterotoxic activity) induced mild to severe architectural changes in the test segments of intestine. The dilated segments contained thick, bloody and mucoid exudates. The results suggested that besides invasiveness and enterotoxigenicity, S. weltevreden possibly possessed factor (s) that damaged intestinal tissue and played part in the pathogenesis of Salmonella gastroenteritis.