Lethal and haemorrhagic activity of Russell's Viper venom--neutralization by polyvalent, monovalent and toxoid antiserum.
Indian J Exp Biol
;
1991 May; 29(5): 456-9
Article
in English
| IMSEAR
| ID: sea-58032
ABSTRACT
Lethal and haemorrhagic activity of Russell's Viper venom was compared against polyvalent bivalent commercial antiserum and monovalent antiserum raised in rabbit. Formaldehyde-detoxified venom offered 7-fold protection against lethal activity and 12.5-fold against haemorrhagic activity of the venom. Whole venom and formaldehyde-detoxified venom along with Freund's complete adjuvant, injected in rabbits produced high titre antiserum. Amongst all the six antiserum tested, the monovalent antiserum raised in rabbit, showed maximum precipitating bands in immunogeldiffusion and immunoelectrophoresis. The toxoid-antiserum offered maximum protection against the venom-induced lethality and the monovalent antiserum offered maximum protection against haemorrhagic activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Viper Venoms
/
Male
/
Hemorrhage
/
Immune Sera
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
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