Chemopreventive action of Phyllanthus urinaria Linn on DMBA-induced skin carcinogenesis in mice.
Indian J Exp Biol
;
2003 Nov; 41(11): 1325-8
Article
in English
| IMSEAR
| ID: sea-58199
ABSTRACT
The inhibition of tumor incidence by hydro-alcoholic extract of the whole plant of P. urinaria was evaluated in 6-7 weeks old female albino mice on two-stage process of skin carcinogenesis induced by a single application of 7,12-dimethylbenz(a)anthracene (50 microg/50 microl of acetone), and 2 weeks later, promoted by repeated application of croton oil (1% in acetone/three times a week) till the end of the experiment (15 weeks). Topical application of the extract at a dose of 5 mg/kg body weight/day for 15 weeks at the peri-initiational stage (i.e., 7 days before and 7 days after DMBA application), promotional stage (i.e., from the time of croton oil application) and both peri and post-initiational stages (i.e., 7 days prior to DMBA application and continued till the end of the experiment) on the shaven backs of the mice recorded a significant reduction in tumor incidence to 50, 33.3 and 16.7% respectively in comparison to the control (i.e., the mice treated with DMBA and croton oil only) where tumor incidence was found to be 81.8%. The average number of papillomas per mouse was also significantly reduced. The results suggest a possible chemopreventive property of P. urinaria against DMBA-induced skin papillomagenesis in mice.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Papilloma
/
Skin Neoplasms
/
Female
/
Croton Oil
/
Plant Extracts
/
Carcinogens
/
Chemoprevention
/
Phyllanthus
/
9,10-Dimethyl-1,2-benzanthracene
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2003
Type:
Article
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