Studies on anti-ulcer properties of Cissampelos mucronata leaf extract.
Indian J Exp Biol
;
1999 Sep; 37(9): 936-8
Article
in English
| IMSEAR
| ID: sea-58247
ABSTRACT
The methanolic extract of the leaves of C. mucronata was screened for anti-ulcer properties using animal models. On isolated guinea pig ileum the extract inhibited contractions evoked by acetylcholine, histamine and serotonin. The extract remarkably decreased the propulsive movement of gastrointestinal content. The extract exhibited significant anti-ulcer activity protecting rats from indomethacin, histamine and stress-induced ulcers. It inhibited the growth of both Gram-positive and Gram-negative microorganisms. The oral LD50 value of the extract in mice was estimated to be 8.5 +/- 0.35 g/kg. The results revealed that the plant C. mucronata has potential medicinal value as an anti-ulcer agent.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Plants, Medicinal
/
Rats
/
Female
/
Male
/
Plant Extracts
/
Plant Leaves
/
Guinea Pigs
/
Animals
/
Mice
/
Anti-Ulcer Agents
Language:
English
Journal:
Indian J Exp Biol
Year:
1999
Type:
Article
Similar
MEDLINE
...
LILACS
LIS