Inhibitory effects of snuff extract on ornithine decarboxylase and aryl hydrocarbon hydroxylase activities in relation to cell proliferation of mouse tongue epithelial cells.

Gijare, P S; Rao, K V; Bhide, S V

Gijare, P S; Rao, K V; Bhide, S V.

Indian J Exp Biol ; 1990 Nov; 28(11): 1012-6

Article in English | IMSEAR | ID: sea-58249

ABSTRACT

ABSTRACT

Effect of snuff extract (SE) on cell proliferation as measured by 3H thymidine (TdR) uptake, induction of ornithine decarboxylase (ODC) and aryl hydrocarbon hydroxylase (AHH) was studied in primary embryonal mouse tongue cultures. Cultures treated with SE in combination with 7,12-dimethylbenz(a)anthracene (DMBA) showed inhibition of cell proliferation and decrease of ODC and AHH activities, compared to control, DMBA, and DMBA + 12-O-tetradecanoylphorbol 13-acetate treated cultures.

Subject(s)

Animals; Aryl Hydrocarbon Hydroxylases/antagonists & inhibitors; Carcinogens; Cell Division; Cells, Cultured; Mouth Neoplasms/etiology; Ornithine Decarboxylase/antagonists & inhibitors; Plants, Toxic; Tobacco, Smokeless/toxicity; Tongue/cytology

Fulltext

XML

Search on Google

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Ornithine Decarboxylase / Plants, Toxic / Tongue / Mouth Neoplasms / Carcinogens / Aryl Hydrocarbon Hydroxylases / Cell Division / Cells, Cultured / Tobacco, Smokeless / Animals Language: English Journal: Indian J Exp Biol Year: 1990 Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

Search on Google