Effect of carbon tetrachloride on rat liver, following parathyroidectomy: histopathological observations.

ABSTRACT

Absence of centrilobular necrosis, cirrhosis and giant hepatic cells with a large nucleus were significant observations in the liver of CCl4 treated rats following unilateral parathyroidectomy. Increased number of mitochondria and presence of binucleated cells indicated hepatic regeneration in unilaterally parathyroidectomized and CCl4 treated rats. Focal necrosis, giant cells and presence of smooth endoplasmic reticulum around the nucleus reflect a slight impairment in regeneration of the liver following bilateral parathyroidectomy and CCl4 administration. The results show that parathyroidectomy interferes in the pathogenesis of necrosis and associated lesions in the liver of CCl4 treated rats. Overall results indicate that unilateral parathyroidectomy afforded better protection than bilateral parathyroidectomy.