Morphine-like activity of some N-substituted amides of met-enkephalin.
Indian J Exp Biol
;
1989 Sep; 27(9): 826-8
Article
in English
| IMSEAR
| ID: sea-58304
ABSTRACT
Opioid activity of a homologous series of met-enkephalin alkylamides was analysed. In guinea pig ileum test, the hexylamide derivative was most active, whereas the isopropylamide derivative was most potent in analgesia test. The results suggest that structural changes of this type at the C-terminus of the pentapeptide improve the opioid activity.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Enkephalin, Methionine
/
Chemistry
/
Chemical Phenomena
/
Amides
/
Guinea Pigs
/
Ileum
/
Animals
/
Morphine
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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