D2-dopamine receptor and alpha2-adrenoreceptor-mediated analgesic response of quercetin.
Indian J Exp Biol
;
2003 Dec; 41(12): 1400-4
Article
in English
| IMSEAR
| ID: sea-58413
ABSTRACT
Quercetin, a bioflavonoid (100-300 mg/kg) produced dose dependent increase in tail-flick latency, the analgesic effect being sensitive to reversal by naloxone (1 mg/kg). Prior treatment with haloperidol (1 mg/kg), D1/D2 receptor antagonist haloperidol, sulpiride (50 mg/kg), a selective D2 receptor antagonist, yohimbine (5 mg/kg), a alpha2-adrenoreceptor antagonist but not by SCH 23390 a, selective D1 receptor antagonist blocked this response. Apomorphine (1 mg/kg) a mixed D1/D2 dopamine receptor agonist, and quinpirole (0.5 mg/kg), a selective D2 receptor agonist also produced antinociception, that was reversed by haloperidol (1 mg/kg), sulpiride (50 mg/kg), but not by yohimbine (5 mg/kg). The antinociceptive action of quercetin (200 mg/kg) was potentiated by D2 agonist quinpirole (0.2 mg/kg). Dopamine D1 receptor agonist SKF38393 (10 and 15 mg/kg) failed to alter the antinociceptive effect of quercetin (200 mg/kg). Quercetin (200 mg/kg) reversed reserpine (2 mg/kg-4 hr) induced hyperalgesia, which was reversed by sulpiride but not by yohimbine. Thus, a role of dopamine D2 and alpha2-adrenoreceptors is postulated in the antinociceptive action of quercetin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Quercetin
/
Reaction Time
/
Female
/
Male
/
Apomorphine
/
2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine
/
Receptors, Dopamine D2
/
Receptors, Adrenergic, alpha-2
/
Analgesics
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2003
Type:
Article
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