Effects of methyl [5 [[4-(2-pyridinyl)-1-piperazinyl]carbonyl]-1H-benzimidazol-2-yl] carbamate on energy metabolism of Ancylostoma ceylanicum and Nippostrongylus brasiliensis.
Indian J Exp Biol
;
1989 Aug; 27(8): 735-8
Article
in English
| IMSEAR
| ID: sea-58465
ABSTRACT
Effects of methyl [5[[4-(2-pyridinyl)-1-piperazinyl] carbonyl] 1H-benzimidazol-2-yl] carbamate (CDRI Comp. 81-470) and mebendazole on the energy metabolism of A. ceylanicum and N. brasiliensis were compared. At 10 and 50 microM concentration both compounds inhibited glucose uptake and its conversion into metabolic endproducts. The shift towards the increased production of lactic acid appeared to be the result of inhibition of PEP carboxykinase and increase in LDH activity. The compounds also caused significant inhibition of ATP production in mitochondria.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Benzimidazoles
/
Carbamates
/
Energy Metabolism
/
Ancylostoma
/
Animals
/
Mebendazole
/
Anthelmintics
/
Nippostrongylus
Country/Region as subject:
South America
/
Brazil
Language:
English
Journal:
Indian J Exp Biol
Year:
1989
Type:
Article
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