Uranyl nitrate induced corpuscular derangement: an early indication of induced acute renal failure.
Indian J Exp Biol
;
1992 Feb; 30(2): 119-21
Article
in English
| IMSEAR
| ID: sea-58539
ABSTRACT
Erythrocyte structure was studied in rat after uranyl nitrate (UN5 mg/kg) intoxication. The study of pathogenic progression of UN induced renal failure (ARF) was confined to the early initiation phase (2 hr), late initiation phase (8 hr) and the maintenance phase (24 hr). Erythrocyte structure has been found to be greatly influenced. The UN induced hemolytic syndrome/hypoxia was accompanied by a marked anisocytosis and poikilocytosis during different phases of ARF, which is characteristic of UN poisoning. Subsequent alterations in erythrocyte structure followed by UN administration or during the pathogenic progression of ARF has clinical and diagnostic importance as the alterations were much distinct prior to the clinical manifestation of ARF even at light microscopic level.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Uranyl Nitrate
/
Blood Cell Count
/
Blood Urea Nitrogen
/
Male
/
Hemoglobins
/
Creatinine
/
Erythrocytes
/
Acute Kidney Injury
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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