Reversal of hepatotoxin-induced pre-fibrogenic events by Emblica officinalis--a histological study.

Mir, A I; Kumar, B; Tasduq, S A; Gupta, D K; Bhardwaj, S; Johri, R K

Mir, A I; Kumar, B; Tasduq, S A; Gupta, D K; Bhardwaj, S; Johri, R K.

Indian J Exp Biol ; 2007 Jul; 45(7): 626-9

Article in English | IMSEAR | ID: sea-58615

ABSTRACT

ABSTRACT

Efficacy of a herbal product of E. officinalis (fruit) (EO) has been evaluated against carbon tetrachloride (CCl4) and thioacetamide (TAA) induced changes in rat liver. Chronic treatment of CCl4 and TAA revealed abnormal histopathology indicative of pre-fibrogenic events. EO reversed such alterations with significant regenerative changes suggestive of its preventive role in prefibrogenesis of liver.

Subject(s)

Animals; Carbon Tetrachloride/pharmacology; Carcinogens/analysis; Drug Evaluation, Preclinical; Liver/drug effects; Liver Cirrhosis; Phyllanthus emblica/metabolism; Plant Extracts/metabolism; Rats; Rats, Wistar; Thioacetamide/pharmacology; Toxins, Biological

Fulltext

XML

Search on Google

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Rats / Thioacetamide / Toxins, Biological / Carbon Tetrachloride / Plant Extracts / Carcinogens / Rats, Wistar / Phyllanthus emblica / Drug Evaluation, Preclinical / Liver Language: English Journal: Indian J Exp Biol Year: 2007 Type: Article

Similar

MEDLINE

LILACS

LIS

Fulltext

XML

Search on Google