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Sustained release implants of chloroquine phosphate for possible use in chemoprophylaxis of malaria.
Indian J Exp Biol ; 2001 Sep; 39(9): 902-5
Article in English | IMSEAR | ID: sea-58625
ABSTRACT
Implants of chloroquine phosphate (CQP) using biodegradable polymer, gelatin (G) and cross-linked gelatin (CLG) were prepared and evaluated to assess their physicochemical properties and in vitro release profile. The mechanism and kinetics of release were studied to correlate the release phenomenon with the formulation parameters. Out of many batches of the implants investigated, the implant prepared with 20% gelatin at 21 drug polymer ratio, 10% crosslinking agent and 2% plasticizer (Batch J) was found to provide optimum release behavior conforming to the requirements of a long term implant for a week. In vivo studies conducted on albino rats showed consistent therapeutic blood level over a period of 7 days. Mean residence time (MRT) of the drug released in the body, calculated as the ratio of the area under the first moment curve (AUMC) to area under concentration time curve (AUC) was 72 hr for implant against 2.42 hr for subcutaneous injection.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plasmodium falciparum / Rats / Female / Male / Chloroquine / Malaria, Falciparum / Chemoprevention / Dose-Response Relationship, Drug / Drug Implants / Gelatin Language: English Journal: Indian J Exp Biol Year: 2001 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Plasmodium falciparum / Rats / Female / Male / Chloroquine / Malaria, Falciparum / Chemoprevention / Dose-Response Relationship, Drug / Drug Implants / Gelatin Language: English Journal: Indian J Exp Biol Year: 2001 Type: Article