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Influence of industrial pollutants on thyroid function in Channa punctatus (Bloch).
Indian J Exp Biol ; 1989 Jan; 27(1): 65-8
Article in English | IMSEAR | ID: sea-58764
ABSTRACT
A 30 day exposure of C. punctatus to sublethal levels of phenol, ammonia, mercuric chloride, cadmium chloride and a mixture of the four resulted in an overall activation of guaiacol peroxidase and depression of iodide peroxidase (IPOD) activity and blood T4 titre. Interestingly enough, in case of 15 day ammonia and 1 day mercury exposures, an increase of IPOD activity was accompanied by a decrease in T4 titre. In general, phenol, mercury, cadmium and the mixture of pollutants were found to inhibit LP activity by 56% to 85% while ammonia inhibited lysosomal protease (LP) activity by 70%. Alterations in acid phosphatase (AP) activity indicate changes in the lysosomal membrane characteristics caused by these toxicants. Considering the concomitant alterations in IPOD, T4, LP and AP it is surmised that thyroid function in C. punctatus is influenced by the pollutants by two pathways, one via IPOD pathway affecting T4 synthesis and the other via lysosomal pathway affecting T4 release.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Peroxidases / Phenols / Thyroid Gland / Thyroxine / Cadmium / Cadmium Chloride / Phenol / Environmental Pollution / Fishes / Ammonia Language: English Journal: Indian J Exp Biol Year: 1989 Type: Article

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Full text: Available Index: IMSEAR (South-East Asia) Main subject: Peroxidases / Phenols / Thyroid Gland / Thyroxine / Cadmium / Cadmium Chloride / Phenol / Environmental Pollution / Fishes / Ammonia Language: English Journal: Indian J Exp Biol Year: 1989 Type: Article