Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Indian J Exp Biol
;
2005 Jul; 43(7): 614-9
Article
in English
| IMSEAR
| ID: sea-58781
ABSTRACT
Cyclooxygenase (COX-2) inhibitors were developed with the hope that they will cause fewer gastrointestinal adverse effects. Ability of selective as well as nonselective COX inhibitors to alter ischemia-reperfusion induced damage of gastric mucosa and hapten-induced colitis in rats has been compared. Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide. Similarly, celecoxib was found to maximally potentiate TNBS-induced colitis, followed by nimesulide and indomethacin. Celecoxib at its highest dose produced maximum deep histological injury. This paradoxic ulcer and colitis aggravating effect of selective COX-2 inhibitors may be explained by suppression of protective prostaglandins generated as a consequence of COX-2 induction in inflammatory states.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Pyrazoles
/
Rats
/
Sulfonamides
/
Male
/
Reperfusion Injury
/
Indomethacin
/
Cyclooxygenase Inhibitors
/
Rats, Wistar
/
Colitis
/
Gastrointestinal Tract
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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