Your browser doesn't support javascript.
loading
Comparative gastrointestinal toxicity of selective cyclooxygenase (COX-2) inhibitors.
Indian J Exp Biol ; 2005 Jul; 43(7): 614-9
Article in English | IMSEAR | ID: sea-58781
ABSTRACT
Cyclooxygenase (COX-2) inhibitors were developed with the hope that they will cause fewer gastrointestinal adverse effects. Ability of selective as well as nonselective COX inhibitors to alter ischemia-reperfusion induced damage of gastric mucosa and hapten-induced colitis in rats has been compared. Celecoxib (10, 20 and 40 mg/kg(-l)) was significantly more potent at aggravating ischemia-reperfusion injury as compared to nimesulide. Similarly, celecoxib was found to maximally potentiate TNBS-induced colitis, followed by nimesulide and indomethacin. Celecoxib at its highest dose produced maximum deep histological injury. This paradoxic ulcer and colitis aggravating effect of selective COX-2 inhibitors may be explained by suppression of protective prostaglandins generated as a consequence of COX-2 induction in inflammatory states.
Subject(s)
Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pyrazoles / Rats / Sulfonamides / Male / Reperfusion Injury / Indomethacin / Cyclooxygenase Inhibitors / Rats, Wistar / Colitis / Gastrointestinal Tract Language: English Journal: Indian J Exp Biol Year: 2005 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: IMSEAR (South-East Asia) Main subject: Pyrazoles / Rats / Sulfonamides / Male / Reperfusion Injury / Indomethacin / Cyclooxygenase Inhibitors / Rats, Wistar / Colitis / Gastrointestinal Tract Language: English Journal: Indian J Exp Biol Year: 2005 Type: Article