Radiation induced peroxidative damage: mechanism and significance.
Indian J Exp Biol
;
2001 Apr; 39(4): 291-309
Article
in English
| IMSEAR
| ID: sea-58857
ABSTRACT
An interest has been generated in free radicals after the discovery of superoxide dismutase. These free radicals cause a number of diseases and are involved in the detrimental effect of ionizing radiation. Efforts have been made to understand their role in damage and death of the cell using lipid peroxidation process. Lipid peroxidation is an important effect of radiation on membranes, which apart from DNA, are critical targets of radiation action. This paper addresses the basic mechanism of radiation induced lipid peroxidation. Various factors, which determine the mode and magnitude of lipid peroxidation, are also discussed. Lipid peroxidation is shown to have importance in understanding the modifications of radiation effects. Efforts are made to show similarities between radiolytic and non-radiolytic lipid peroxidation. Recent findings related to the close link between radiation-induced lipid peroxidation and apoptosis are likely to open new avenues for future research and to develop new approaches for radiomodification of biological effects.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Radiobiology
/
Humans
/
Lipid Peroxidation
/
Apoptosis
/
Free Radicals
/
Animals
/
Membrane Lipids
Language:
English
Journal:
Indian J Exp Biol
Year:
2001
Type:
Article
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