Effects of calcium on phthalocyanine sensitized photohemolysis.
Indian J Exp Biol
;
1998 Feb; 36(2): 152-6
Article
in English
| IMSEAR
| ID: sea-58919
ABSTRACT
Influence of divalent Ca2+ ions in sulphonated chlorophthalocyanine (ClAlPcS2) induced photohemolysis in rabbit red blood cells has been investigated. Loading of excess Ca2+ to ClAlPcS2 sensitized RBC suspension enhanced hemolysis in a concentration dependent manner. Protein kinase C (PKC) inhibitor chlorpromazine and cation chelator EDTA reduced Ca2+ enhanced photohemolysis. Photohemolysis increased with calcium channel blockers diltiazem and nifidipine. Enhancement in photohemolysis by Ca2+ ions can arise either by its ability to liberate Fe2+ bound to phosphatidylserine or by stimulation of PKC. Inability of calcium channel blockers to prevent Ca2+ influx following photodynamic treatment of red blood cells suggest nonspecific leakage rather than involvement of Ca2+ channels in erythrocytes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rabbits
/
Kinetics
/
Calcium Channel Blockers
/
Chlorpromazine
/
Calcium
/
Egtazic Acid
/
Photosensitizing Agents
/
Erythrocytes
/
Hemolysis
/
Indoles
Language:
English
Journal:
Indian J Exp Biol
Year:
1998
Type:
Article
Similar
MEDLINE
...
LILACS
LIS