Effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity in rats.
Indian J Exp Biol
;
2005 May; 43(5): 445-9
Article
in English
| IMSEAR
| ID: sea-58928
ABSTRACT
In order to find out the effect of chronic ethanol administration on testicular antioxidant system and steroidogenic enzyme activity, male rats fed with ethanol 1.6g/kg body weight per day for four weeks were studied. Besides a drastic reduction in body and testis weight, there was decrease in ascorbic acid, reduced glutathione and activities of superoxide dismutase, catalase, glutathione reductase and glutathione peroxidase in the testicular tissue of the treated animals. Simultaneously, there was increase in lipid peroxidation and glutathione S-transferase activity. Activities of 3 beta-hydroxy steroid dehydrogenase and 17 beta-hydroxy steroid dehydrogenase were also found decreased in the treated animals. The results indicate that chronic ethanol administration resulted in increase in oxidative stress and decrease in the activities of steroidogenic enzymes in the rat testes.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Testis
/
Male
/
Reactive Oxygen Species
/
Rats, Wistar
/
Ethanol
/
17-Hydroxysteroid Dehydrogenases
/
3-Hydroxysteroid Dehydrogenases
/
Animals
/
Antioxidants
Language:
English
Journal:
Indian J Exp Biol
Year:
2005
Type:
Article
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