Effect of amaranth leaves on dimethylhydrazine-induced changes in multicomponent antioxidant system of rat liver.
Indian J Exp Biol
;
2004 Jun; 42(6): 595-600
Article
in English
| IMSEAR
| ID: sea-59000
ABSTRACT
Effect of prefeeding dehydrated amaranth (A. gangeticus) leaves at 10 and 20% levels on a chemical toxicant, dimethylhydrazine (DMH)-induced free radical stress in rat liver was evaluated. DMH-induced rise in hepatic malondialdehyde (MDA), was diminished by AL. AL intake resulted in a significant increase in hepatic glutathione (GSH). The feeding of AL at 10% level increased the hepatic glucose-6-phosphate dehydrogenase (G-6-PDH) activity, while that at 20% level increased the hepatic glutathione reductase (GSSGR) as well, in addition to G-6-PDH. Amaranth leaves at 10 and 20% levels of feeding diminished the hepatic superoxide dismutase and glutathione peroxidase (GSH-Px) activities. DMH influenced adversely the hepatic antioxidant enzyme activities. Simultaneous administration of DMH and feeding of AL enhanced the DMH-induced decrease in hepatic GSH-Px. DMH enhanced formation of micronuclei was reverted significantly by AL intake. Hence, it was concluded that the consumption of AL at 20% level reduced DMH-induced impaired antioxidant status in rat liver.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Rats
/
Superoxide Dismutase
/
Body Weight
/
Bone Marrow
/
Male
/
Plant Extracts
/
Lipid Peroxidation
/
Rats, Wistar
/
Colon
Language:
English
Journal:
Indian J Exp Biol
Year:
2004
Type:
Article
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