Hepatoprotective activity of six polyherbal formulations in CCl4-induced liver toxicity in mice.
Indian J Exp Biol
;
2009 Apr; 47(4): 257-63
Article
in English
| IMSEAR
| ID: sea-59038
ABSTRACT
To evaluate pretreatment of six polyherbal liquid formulations (PLFs) commercially available in India, on CCl4-induced liver injury, Swiss albino mice were treated for 7 days with distilled water or PLFs (2.6 and 5.2 ml/kg body weight/day, po) followed by single sc injection of 50% (v/v) CCl4 in arachis oil at a dose of 1 ml/kg. The serum biochemical parameters such as alanine transaminases, aspartate transaminases and alkaline phosphatase were estimated. Phenobarbitone-induced sleeping time and liver histopathology were also carried out. CCl4-treated animals showed significant increase in the levels of liver enzymes, phenobarbitone-induced sleeping time and revealed fatty changes and centrizonal necrosis on histological examination of liver indicating hepatic damage. When pretreated with PLFs at a dose of 5.2 ml/kg body weight/day, the CCl4-induced changes were significantly reversed. The pretreatment with PLFs can prevent acute liver damage induced by CCl4 only at a higher dose. Therefore, it is suggested that a dose adjustment of these PLFs may be necessary for their optimal effects in human liver diseases.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Phenobarbital
/
Sleep
/
Time Factors
/
Carbon Tetrachloride
/
Plant Extracts
/
Protective Agents
/
Chemical and Drug Induced Liver Injury
/
Liver
/
Liver Diseases
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
2009
Type:
Article
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