Comparative effects of mast cell degranulators on perfused systemic blood vessels of Bufo melanostictus and Rana tigrina.
Indian J Exp Biol
;
1992 Dec; 30(12): 1176-80
Article
in English
| IMSEAR
| ID: sea-59211
ABSTRACT
Three agents known to induce release of mast cell constituents, viz. polymyxin, compound 48/80 and polysorbate-80, were evaluated for effect on perfused blood vessels of R. tigrina and B. melanostictus. The mast cell degranulators caused vasoconstriction in frog and toad, except that for P-80 whose responses in toad were equivocal. Toads showed a general low responsiveness in comparison to frogs. Pharmacologic intervention with pheniramine, metergoline, hydergine, atropine and mecamylamine, respectively ruled out role of histamine, 5-HT, catecholamine or acetylcholine or even autonomic mechanisms in the above phenomena. The observations are suggestive of phylogenetic differences in biochemical profile of mast cells in amphibian species.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Perfusion
/
Polysorbates
/
Ranidae
/
Tachyphylaxis
/
Vasoconstriction
/
Bufonidae
/
Histamine
/
Serotonin
/
Polymyxins
/
P-Methoxy-N-methylphenethylamine
Language:
English
Journal:
Indian J Exp Biol
Year:
1992
Type:
Article
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