Plasma CRP level predicts left ventricular function and exercise capacity in patients with acute myocardial infarction.
Indian Heart J
;
2005 Jan-Feb; 57(1): 54-7
Article
in English
| IMSEAR
| ID: sea-5930
ABSTRACT
BACKGROUND:
C-reactive protein estimation can help in predicting short- and long-term prognosis after acute myocardial infarction. High plasma C-reactive protein level in the acute phase strongly indicates a poor clinical outcome of the patients with myocardial infarction. METHODS ANDRESULTS:
One hundred consecutive patients admitted with ST elevation myocardial infarction in the intensive coronary care unit in our hospital who were able to do symptom-limited treadmill test during early recovery phase were studied. Plasma C-reactive protein was measured at the time of admission by immunoturbidity method. The normal value of the C-reactive protein was taken as 0.8 mg/dl. Echocardiographic study was done on day three of admission and ejection fraction was estimated by modified Simpson's method. Symptom-limited treadmill exercise test was done in all the patients. Patients were classified into two groups based on level of C-reactive protein those with low C-reactive protein level (1.26 +/- 0.91 mg/dl, n=40) and those with high C-reactive protein level (6.52 +/- 3.97 mg/dl, n=60). Ejection fraction was lower in high C-reactive protein group (46.7 +/- 11.9%) compared to low C-reactive protein group (56.9 +/- 7.7%) (p = 0.011). Exercise capacity was lower in high C-reactive protein group (2.8 +/- 1.4 METs) compared to low C-reactive protein group (5.5 +/- 2.5 METs) p = 0.027).CONCLUSIONS:
C-reactive protein levels are an index of the severity of myocardial necrosis which translate to worse left ventricular function. Higher the C-reactive protein level, lower the ejection fraction and worse may be the prognosis.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Stroke Volume
/
Female
/
Humans
/
Male
/
C-Reactive Protein
/
Predictive Value of Tests
/
Ventricular Function, Left
/
Exercise Tolerance
/
Ventricular Dysfunction, Left
/
Middle Aged
Type of study:
Prognostic study
Language:
English
Journal:
Indian heart j
Year:
2005
Type:
Article
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