Effect of some chemical radioprotectors on mouse bone marrow.
Indian J Exp Biol
;
1993 Oct; 31(10): 843-6
Article
in English
| IMSEAR
| ID: sea-59313
ABSTRACT
Effect of HT, AET and Se on mice bone marrow has been studied by counting bone marrow micronucleated cells and endogenous spleen colony count (CFU-S). Combination of HT and AET used as a radioprotector has not caused any significant variation in any of the parameter studied when administered once, it increases bone marrow micronucleated cells and decreases CFU-S slightly after daily administration for 7 days. The individual constituent of the combination administered singly does not increase micronucleated cell number. Seven consecutive doses of HT + AET and same in combination with Se enhances micronucleated cells to a higher level. Daily injection of Se alone up to 7 days also causes an increase in micronucleated cells upto same level. CFU-S pool does not show any significant change in number of bone marrow cells through out the study except in the groups where animals were treated with Se.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Radiation-Protective Agents
/
Selenium
/
Bone Marrow
/
Female
/
Male
/
5-Hydroxytryptophan
/
Colony-Forming Units Assay
/
Beta-Aminoethyl Isothiourea
/
Drug Evaluation, Preclinical
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1993
Type:
Article
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