Protective antioxidant effect of vitamins C and E in streptozotocin induced diabetic rats.
Indian J Exp Biol
;
2000 Feb; 38(2): 101-4
Article
in English
| IMSEAR
| ID: sea-59344
ABSTRACT
We have investigated the protective effect of vitamin C and E together supplementation on oxidative stress and antioxidant enzyme activities in the liver of streptozotocin-induced diabetic rats, unsupplemented diabetic and control rats. We also determined the levels of both the vitamins and oxidative stress in plasma. Vitamin supplementation in diabetic rats lowered plasma and liver lipid peroxidation, normalised plasma vitamin C levels and raised vitamin E above normal levels. In liver, the activity of glutathione peroxidase was raised significantly and that of glutathione-S-transferase was normalised by vitamin supplementation in diabetic rats. The levels of lipid peroxidation products in plasma and liver of vitamin-supplemented diabetic rats and activities of antioxidant enzymes in liver suggest that these vitamins reduce lipid peroxidation by quenching free radicals.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Ascorbic Acid
/
Rats
/
Vitamin E
/
Female
/
Lipid Peroxidation
/
Rats, Sprague-Dawley
/
Diabetes Mellitus, Experimental
/
Liver
/
Animals
/
Antioxidants
Language:
English
Journal:
Indian J Exp Biol
Year:
2000
Type:
Article
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