Chemopreventive efficacy of betel leaf extract and its constituents on 7,12-dimethylbenz(a)anthracene induced carcinogenesis and their effect on drug detoxification system in mouse skin.
Indian J Exp Biol
;
1991 Apr; 29(4): 346-51
Article
in English
| IMSEAR
| ID: sea-59380
ABSTRACT
Effects of topically applied betel leaf extract (BLE) and its constituents. beta-carotene, alpha-tocopherol, eugenol and hydroxychavicol on 7,12-dimethylbenz(a)anthracene (DMBA) induced skin tumors were evaluated in two strains of mice. BLE, beta-carotene and alpha-tocopherol, significantly inhibited the tumor formation by 83, 86, 86% in Swiss mice and 92, 94 and 89% in male Swiss bare mice respectively. Hydroxychavicol showed 90% inhibition in Swiss bare mice at 24 weeks of treatment. Eugenol showed minimal protection in both strains of mice. The mean latency period and survivors in BLE, beta-carotene, alpha-tocopherol and hydroxychavicol treated groups were remarkably high as compared to DMBA alone treated group. Intraperitoneal injection of betal leaf constituents showed a significant effect on both glutathione and glutathione S-transferase levels in the Swiss mouse skin.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Areca
/
Plants, Medicinal
/
Skin Neoplasms
/
Female
/
Male
/
Inactivation, Metabolic
/
9,10-Dimethyl-1,2-benzanthracene
/
Animals
/
Mice
/
Antineoplastic Agents, Phytogenic
Language:
English
Journal:
Indian J Exp Biol
Year:
1991
Type:
Article
Similar
MEDLINE
...
LILACS
LIS