In vitro and in vivo therapeutic activity of Parthenium hysterophorus against Trypanosoma evansi.
Indian J Exp Biol
;
1995 Nov; 33(11): 894-6
Article
in English
| IMSEAR
| ID: sea-59392
ABSTRACT
Crude 50% ethanolic extract of P. hysterophorus flowers exhibited trypanocidal activity in vitro at all the four concentrations tested i.e. 5, 50, 500 and 1000 micrograms/ml. In vivo trial revealed that the extract exerted antitrypanosomal effect at doses of 100 and 300 mg/kg body wt, i.p. as evidenced by significantly reduced (P < 0.01) mean parasitaemia on days 3, 4, 5 and 6 when compared with untreated control group. Further at 100 and 300 mg/kg, body wt doses, the survival period was significantly (P < 0.05) prolonged as compared to control group. The extract was, however, found toxic to the animals at 1000 mg/kg dose.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Trypanocidal Agents
/
Trypanosoma
/
Trypanosomiasis
/
Female
/
Male
/
Plant Extracts
/
Animals
/
Mice
Language:
English
Journal:
Indian J Exp Biol
Year:
1995
Type:
Article
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