Effect of long-term administration of melatonin on adrenal histomorphology of the Indian desert gerbil Meriones hurrianae Jerdon.
Indian J Exp Biol
;
1995 Nov; 33(11): 833-6
Article
in English
| IMSEAR
| ID: sea-59452
ABSTRACT
Melatonin treatment for 8 weeks resulted in a significant increase (P < 0.01) in weights of the adrenal glands, in both male and female, M. hurrianae. The weight increase was not related to the time of administration of melatonin. Histology of adrenal glands in melatonin treated gerbils revealed a stimulatory response. In treated gerbils, adrenal cortex exhibited significant hypertrophy with enlarged nuclei and degranulated cytoplasm. Signs of hypertrophy were also evident in the adrenal medulla. The physiological significance of this response is not yet clear. It remains to be clarified if the hypertrophy indicates enhanced synthesis of corticosteroids.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Organ Size
/
Female
/
Male
/
Drug Administration Schedule
/
Gerbillinae
/
Adrenal Glands
/
Hypertrophy
/
Animals
/
Melatonin
Language:
English
Journal:
Indian J Exp Biol
Year:
1995
Type:
Article
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