Thermosensitive and pH mechanisms regulating urine formation.

ABSTRACT

The study was undertaken to investigate the effect of infusion of isotonic saline of different pH (2, 3, 9 and 10) and different temperatures (cold 4 degrees and warm 40 degrees C) in urinary bladder on rate of renal urine formation. The volume of fluid (isotonic saline) infused was 100 ml in all the cases. Presence of alkaline saline (pH-9 and pH-10) and warm saline in urinary bladder, decreased the rate of urine flow whereas acidic and cold saline increased the rate of urine flow significantly. (P < 0.05 and < 0.0001 respectively). The observed effects disappeared when 4% xylocaine in 100 ml saline was infused and evacuated prior to infusion of fluids of different pH and temperature. The observation suggests existence of chemosensitive and thermosensitive mechanisms in the vesical mucosa regulating urine formation by the kidney.