Effect of chloroquine on rat liver mitochondria.
Indian J Exp Biol
;
1994 Nov; 32(11): 797-9
Article
in English
| IMSEAR
| ID: sea-59612
ABSTRACT
Chloroquine causes an increase in phospholipid and a decrease in cholesterol in liver mitochondria. A significant decrease in the activities of mitochondrial inner membrane enzymes such as NADH dehydrogenase, succinate dehydrogenase and cytochrome c oxidase is observed. Decrease in cytochrome contents and respiratory control ratio, shown by a decrease in state 3(+ADP) and an increase in state 4 (-ADP), implies decreased ATP synthesis following chloroquine administration. The results confirm drug-induced inhibition of mitochondrial respiration, thereby impairing availability and utilisation of energy.
Full text:
Available
Index:
IMSEAR (South-East Asia)
Main subject:
Rats
/
Male
/
Mitochondria, Liver
/
Chloroquine
/
Rats, Wistar
/
Animals
Language:
English
Journal:
Indian J Exp Biol
Year:
1994
Type:
Article
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